An additional dehydratase-like activity is required for lankacidin antibiotic biosynthesis

Jeroen S. Dickschat, Olivia Vergnolle, Hui Hong, Stephen Garner, Susanna R. Bidgood, Hannah C. Dooley, Zixin Deng, Peter F. Leadlay*, and Yuhui Sun*

ChemBioChem 2011, 12(16):2408-2412

Epub Date: 27 September 2011

DOI: 10.1002/cbic.201100474


Lankacidin biosynthesis is processed by an unusual NRPS/PKS. A previously unrecognised dehydratase domain was shown in knockout experiments to act together with thediscrete dehydratase LkcB in lankacidin biosynthesis and may control the switch from the iterative to the modular modeof operation that is implied in this system.