《美国科学院院刊》（Proceedings of the National Academy of Sciences of the United States of America）今日在线发表了我们基于链霉菌三维基因组解析及高产天然产物的研究进展。该研究以饱含天然产物生物合成基因资源的链霉菌为研究材料，通过揭示和利用染色质高级结构与天然产物生物合成基因簇表达的规律，为高产天然产物提供了一个新的维度和视角。邓梁和北京生物技术研究所赵志虎研究员为该论文共同第一作者。

Today, we published our research progress in Proceedings of the National Academy of Sciences of the United States of America on the three-dimensional genome analysis of Streptomyces and the overproduction of natural products. This study uses Streptomyces, which is rich in natural products, as the research material, and provides a new dimension and perspective for overproduction of natural products by revealing and utilizing the correlation between the high-level structure of chromatin and the expression of natural product biosynthetic gene clusters.

《自然・通讯》（Nature Communications）今日在线发表了我们关于聚酮合酶（Polyketide Synthase）研究的最新进展，该研究解析了来自具有优良的抗真菌、抗肿瘤活性天然产物——阿扎霉素F（Azalomycin F）模块化聚酮合酶装配线的进化过程，揭示了模块间独特的相互作用与装配线非经典作用机制的相关性，并实现了装配线的理性设计和定向改造。这也是继2017年和2020年在《德国应用化学》（Angewandte Chemie International Edition）发表相关工作以来，对该独特聚酮合酶研究取得的最新进展。这为深入理解模块化聚酮合酶装配线及进化过程提供了新的见解与灵感。翟贵发和朱妍为本文并列第一作者。

Today, we published a latest research advance in Nature Communications on a marvelous polyketide synthase. We analyzed the evolution process of the modular polyketide synthase assembly line from Azalomycin F, a natural product with excellent antifungal and anti-tumor activity and revealed the correlation between the unique interaction between modules and the non-classical mechanism of the assembly line. Based on it, we also realized the rational design and directional transformation of the assembly line. This is the latest progress on this unique polyketide synthase since the relevant work was published in Angewandte Chemie International Edition in 2017 and 2020. This provides new insights and inspiration for in-depth understanding of the modular polyketide synthase assembly line and evolution process.