《德国应用化学》（Angewandte Chemie International Edition）今日发表了我们在微生物聚酮合酶生物合成机制研究方面的一项新发现：即在链霉菌Streptomyces sp. 211726所产生的36元大环内酯类聚酮化合物――――阿扎霉素（Azalomycin F）中，首次揭示其聚酮合酶中一种可自动开关的烯醇还原酶结构域，这一新颖而独特发现不仅拓宽和丰富了人们对聚酮合酶经典线性装配模式的认识，同时也将为新型聚酮化合物的创制提供理论指导。博士生徐韡和翟贵发为本文共同第一作者。
孙宇辉赴韩国济州岛参加第十八届国际放线菌生物学大会，并做分会口头报告。
《美国化学会-化学生物学》（ACS Chemical Biology）今日发表我们在利福霉素结构类似物――曲张链丝菌素（Streptovaricin）生物合成及其抗MRSA活性的阶段性研究进展。该研究从武汉大学校园分离得到一株放线菌出发，对其中所产生的具有抗MRSA活性的天然产物曲张链丝菌素中多个细胞色素P450编码基因及其功能进行了系统的研究，并揭示出其重要构效关系。这为定向理性改造曲张链丝菌素，并将其开发成高效抗MRSA药物奠定了坚实的理论基础。
We just reported a research progress in ACS Chemical Biology on the functional analysis of cytochrome P450s involved in rifamycin-like streptovaricin biosynthesis and generation of anti-MRSA analogues. A bioassay-guided investigation of Streptomyces spectabilis M2017417 isolated from Wuhan University campus led to the characterization of streptovaricins as potent compounds against MRSA, and identification of significant structure-activity relationship. This work provides meaningful information on rational modification of streptovaricins, and demonstrates the utility of the engineering of streptovaricins to yield novel anti-MRSA molecules.
英国皇家学会、英国爱丁堡皇家学会院士Thomas J. Simpson教授和英国爱丁堡皇家学会院士David O' Hagan教授应邀联袂来我室访问，并做客珞珈讲坛。
Prof. Thomas J. Simpson (FRS, FRSE) from University of Bristol and Prof. David O’ Hagan (FRSE) from University of St Andrews were invited to visit our lab, and gave presentations of "NEW drugs from OLD pathways---Teaching nature new tricks" and "The fluorinase: My PET project", respectively, in Luo Jia Lecture of Wuhan University.