2018年1月22日

《美国科学院院刊》(Proceedings of the National Academy of Sciences of the United States of America)今日在线发表了我们关于庆大霉素甲基化代谢网络的研究论文这也是继20142015年连续在Cell》子刊《Chemistry & Biology》发表庆大霉素生物合成机制系列研究成果以来本课题组剑桥大学Peter  F. Leadlay教授合作再次在该领域取得的最新进展。在这项研究中,我们全面揭示了一个全新的庆大霉素甲基化立体交叉代谢网络,为庆大霉素复杂多组分的产生提供了合理的解释,更重要的是为理性获得高效低毒庆大霉素单组分提供了清晰的代谢线路图。李思聪和郭俊红为本文共同第一作者。  

We just published a paper in Proceedings of the National Academy of Sciences of the United States of Americaon a methylation network of gentamicin biosynthesis and also a long-missing remote gene encoding an essential methyltransferase which is decisive for the proportions of the five major components present in the gentamicin C complex. It is the latest progress on gentamicin biosynthesis of our long-term collaboration with Prof. Peter F. Leadlay’s group at University of Cambridge. These findings now fully account for the methylation pattern in gentamicins and open the way to produce single componentsfor semisynthesis of next-generation aminoglycoside antibiotics.
2018年4月6日

英国圣安德鲁斯大学Rebecca Goss教授应邀来我室访问,并举行学术报告。


Prof. Rebecca Goss from University of St Andrews was invited to visite our lab and gave a presentation of "Blending Synthetic Chemistry with Synthetic Biology in vivo to Enable Access to New to Nature Natural Products".
2018年6月24日

而今迈步从头越,开启人生新征途!

祝贺杨安纳、张俊、孙洋洋、邱诚斌和陈旭顺利毕业,并获得硕士学位。


Congratulations to Anna Yang, Jun Zhang, Yangyang Sun, Chengbin Qiu and Xu Chen on their gradulations and achieving their Master degrees.
2018年9月14日

孙宇辉赴英国剑桥大学参加Peter F. Leadlay学术成就研讨会。


Prof. Yuhui Sun attended a symposium held at the University of Cambridge to celebrate Peter F. Leadlay's outstanding scientific achievements.

2018年9月17日

孙宇辉赴英国华威大学看望在Gregory L. Challis实验室开展博士后和攻读博士学位的本实验室毕业生黄川博士和简心韵。


Prof. Yuhui Sun went to the University of Warwick to visit our lab graduates Dr. Chuan Huang and Xinyun Jian who are working in Prof. Gregory L. Challis's group as postdoctor and Ph.D. student, respectively.

2018年10月20日

孙宇辉带领研究生翟贵发、李思聪、钟智愚、王建参加2018年中国微生物学会学术年会,并做开幕式大会主旨报告。


Prof. Yuhui Sun attended the Annual Symposium of Chinese Society for Microbiology held in Nanchang during 20-22 October 2018, and gave a plenary presentation in the openning ceremony.